(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5

Identification
Properties
Safety Data
Specifications & Other Information
Links

Identification

CAS Number

110351-94-5

Name

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Synonyms

(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizin-3,6,10(4H)-trion [German] [ACD/IUPAC Name]
(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione [ACD/IUPAC Name]
(4S)-4-Éthyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione [French] [ACD/IUPAC Name]
(s)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro-6-oxa-3a-aza-cyclopenta[b]naphthalene-1,4,7-trione
1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (4S)- [ACD/Index Name]
(4S)-4-ETHYL-4-HYDROXY-1H,3H,4H,6H,7H,8H,10H-PYRANO[3,4-F]INDOLIZINE-3,6,10-TRIONE
(4S)-4-ETHYL-4-HYDROXY-1H,7H,8H-PYRANO[3,4-F]INDOLIZINE-3,6,10-TRIONE
(4S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione
(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f
(4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE
(S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3
(S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
[110351-94-5]
110351-94-5 [RN]
1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione,4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-
ANW-72103
CTK4A6861
IGKWOGMVAOYVSJ-ZDUSSCGKSA-N
MFCD09833229
MFCD17011873 [MDL number]
MolPort-005-933-313
SCHEMBL614060
ZINC01616399

Molecular Structure

Structure of (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5

Structure of (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5

SMILES

CC[C@@]1(c2cc3n(c(=O)c2COC1=O)CCC3=O)O

StdInChI

InChI=1S/C13H13NO5/c1-2-13(18)8-5-9-10(15)3-4-14(9)11(16)7(8)6-19-12(13)17/h5,18H,2-4,6H2,1H3/t13-/m0/s1

StdInChIKey

IGKWOGMVAOYVSJ-ZDUSSCGKSA-N

Molecular Formula

C13H13NO5

Molecular Weight

263.246

MDL Number

MFCD17011873

Properties

Appearance

Light yellow solid

Melting Point

185℃

Safety Data

Signal Word

Warning

WGK Germany

3

Specifications and Other Information of Our (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5

Standard

Enterprise standard

Identification Methods

HNMR,HPLC

Purity

95%min

Specific Optical Rotation

+76°~+78° (c 0.62, CHCl3)

Storage

Preserved in tight containers

Application

It is the key intermediate for the synthesis of a series of (20S)-camptothecin analogues. Since its isolation from the Chinese plant Camptothecaacuminata by Wall et al. In 1966, (20S)-camptothecin, a pent acyclic natural alkaloid, has re-emerged as one of the most important lead compounds for the discovery of new and selective anticancer drugs because of the disclosure of its unique mechanism of action as a selective inhibitor DNA topoisomerase Ⅰ, a process causing irreversible DNA damage and subsequent cell death. Three camptothecin derivatives with high antitumor activity, topotecan, belotecan, and irinotecan, have been launched as anticancer drugs in clinical practice, and many other analogues are at various stages of clinical development.

General View of Documents

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5 NMR

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5 NMR

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5 HPLC

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5 HPLC

Links

This product is developed by our R&D company Caming Pharmaceutical Ltd(http://www.caming.com/), and here is the corresponding linkhttp://www.caming.com/s-4-ethyl-4-hydroxy-78-dihydro-1h-pyrano34-findolizine-36104h-trione-cas-110351-94-5/

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Disclaimer

This product is for research and development purpose only which may not be used directly as drugs, food, cosmetics or for any other non-R&D purpose. It may be toxic or hazardous, and should be handled only by qualified individuals trained in laboratory procedures. The buyer will be responsible to warn and inform any person that may be in contact with the product of the potential risks and hazards, as well as to ensure that purchase, use and disposal of the product comply with local laws and regulations.