Travoprost CAS 157283-68-6

Identification
Properties
Safety Data
Specifications & Other Information
Links

Identification

CAS Number

157283-68-6

Name

Travoprost

Synonyms

(+/-)-16-(M-TRIFLUOROMETHYLPHENOXY)TETRANORPROSTAGLANDIN F2
15(S)-FLU-IPR
15(S)-FLUPROSTENOL ISOPROPYL ESTER
(+)-9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
9ALPHA,11ALPHA,15S-TRIHYDROXY-16(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
(+)-FLUPROSTENOL ISOPROPYL ESTER
FLUPROSTENOL ISOPROPYL ESTER
FLU-IPR
1-methylethyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate
Travatan
Travatan Z

Molecular Structure

structure of Travoprost CAS 157283-68-6

SMILES

FC(F)(F)c2cc(OC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)CC=C/CCCC(=O)OC(C)C)ccc2

StdInChI

InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1

StdInChIKey

MKPLKVHSHYCHOC-AHTXBMBWSA-N

Molecular Formula

C26H35F3O6

Molecular Weight

500.5477

Properties

Appearance

Light yellow to almost colourless oil

Flash Point

307.5°C

Boiling Point

584.8°C at 760 mmHg

Density

1.245g/ml

Refractive Index

1.547

Safety Data

Symbol

flame-jpgexclamation-mark-jpgGHS02, GHS07

Risk Statements (Europe)

11-36/37/38

Safety Statements (Europe)

16-26-36

Specifications and Other Information of Our Travoprost CAS 157283-68-6

Standard

USP34

Identification Methods

HPLC, TLC

Assay

96.0%-102%

Solubility

Soluble in chloroform,ethyl acetate, acetone, practically insoluble in water

Specific Rotation

+52°~+58°,(C=1 CH2Cl2)

Water

≤1.0%

Related Compounds

Epoxide derivative ≤0.40%
15-epi Diastereomer ≤0.1%
5,6-trans Isomer ≤3.5%
15-Keto derivative ≤0.3%
Any other impurities ≤0.1%
Total other impurity ≤1.0%

Related Solvents

Isopropanol ≤0.5%
Ethyl acetate ≤0.25%
n-Hexane ≤0.029%
Ethanol ≤0.5%

Known Application

Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure.

Package

Plastic bag inside and paper drum outside.

Productivity

kg scale/month

Storage

Glass bottle, 2-8°C for shipment and 0 ℃ for long time storage

General View of Documents

Travoprost-CAS-157283-68-6-NMR1

Travoprost-CAS-157283-68-6-NMR1

Travoprost-CAS-157283-68-6-NMR2

Travoprost-CAS-157283-68-6-NMR2

Travoprost-CAS-157283-68-6-NMR3

Travoprost-CAS-157283-68-6-NMR3

Available Impurities

Impurity 1
Name: Epoxide Derivative
Chemical Name: (5Z)-(9S,11R,15S)-9,11,15-Trihydroxy-13,14-epoxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)
Structure-of-1314-Epoxy-derivative-of-Travoprost
Impurity 2
Name: 15-epi Diastereomer
Chemical Name: (5Z,13E)-(9S,11R,15S)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure-of-15-epi-Diastereomer

Structure-of-15-epi-Diastereomer

Impurity 3
Name: 5,6-trans Isomer
Chemical Name: (5E,13E)-(9S,11R,15R)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure-of-56-trans-Isomer

Structure-of-56-trans-Isomer

Impurity 4
Name: 15-keto derivative
Full Name: (5Z,13E)-(9S,11R)-9,11-Dihydroxy-15-oxo-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
CAS: 404830-45-1
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure-of-15-keto-Travoprost-CAS-404830-45-1

Structure-of-15-keto-Travoprost-CAS-404830-45-1

Links

This product is developed by our R&D company Caming Pharmaceutical Ltd(http://www.caming.com/), and here is the corresponding linkhttp://caming.com/travoprost-cas-157283-68-6-2/

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Disclaimer

This product is for research and development purpose only which may not be used directly as drugs, food, cosmetics or for any other non-R&D purpose. It may be toxic or hazardous, and should be handled only by qualified individuals trained in laboratory procedures. The buyer will be responsible to warn and inform any person that may be in contact with the product of the potential risks and hazards, as well as to ensure that purchase, use and disposal of the product comply with local laws and regulations.